Weapon equipments acquisition and demonstration has become more and more prominent in the informationalized war conditions while operational effectiveness evaluation is its core part. The research purposes of operational effectiveness evaluation in various functional departments, such as the institute of military systems analysis and the general design department of the industry, could be significantly different, which in turn demands weapon system operational effectiveness evaluation to fully reflect the impact of various operational alternatives and general design alternatives on operational effectiveness in order to explore the optimal alternatives. The complexity and uncertainty of weapon systems operational effectiveness evaluation make traditional analysis methods or expert evaluation methods less effective to solve problems. Simulation based operational effectiveness evaluation is an efficient solution. The increased complexity of both weapon equipments and system-of-systems combat process, however, entails the system-of-systems combat simulation as the most successful solution to weapon system operational effectiveness evaluation.System-of-systems combat simulation will face similar problems of complexity and uncertainty of operational effectiveness evaluation. The solutions of the above problems must start with the basic links of system-of-systems combat simulation, which are modeling and experimentation. Model specification is the foundation, which is required to be able to flexibly describe abstract battlefields and represent various complicated and uncertain relationships. Experimentation is the means, which requires simulation experiments to be designed scientifically to explore those complex and uncertain experimental spaces to achieve analysis conclusion with high creditability.The thesis uses missile system-of-systems combat simulation as the application background and focuses on the research of modeling and experimentation of system-of-systems combat simulation. The contents are summarized into the following parts:(1) After analyzing the problems of simulation model specification in the field of missile system-of-systems combat simulation application, the hierarchical description and composition method based on system-of-systems, entity and behavior is proposed as the modeling methodology of system-of-systems combat simulation, which is SEB composable modeling methodology. Then, the reference model of SEB methodology and the modeling reference view of various hierarchies are discussed.(2) Based on the analysis of the composition and characteristics of battlefield combat system-of-systems, as well as the elements and characteristics required for entity modeling and system-of-systems modeling, the entity and system-of-systems modeling methods, as the framework of SEB methodology, which support dynamic structure modeling of system-of-systems simulation, are studied. The rigorous formal specification of entity model and system-of-systems model are also established.