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Bone Marrow Stromal Cells Differentiate into Neurons and Treatment of PD Rat with the Differentiated
Objective: Bone marrow stromal cells (BMSCs) can differentiate into bone, cartilage, muscle, neuron, and glia both in vivo and in vitro. Recently, BMSCs differentiated into neuron and treated nervous system diseases have become the focus. Bu....
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The Effect of T Lymphocyte on the Repairment of Firearm Sciatic Nerve's Disrupted Injury
Background: The successful regeneration of the firearm peripheral nerve's disrupted injury is still a problem to be solved. Recently the study on Neuro-immuno-endocrinology showed that the specific T lymphocytes induced by the injury of the....
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Endoscopic Endonasal Transphenoidal Approaches to the Sellar Region: Anatomic Study and Clinical Appl
ObjectivesTo establish the anatomic basis for the endoscopic endonasal transphenoidal approaches to the sellar region.Methods15 adult cadaveric heads were studied: 13 were fixed with formalin, 8 of them were artery-injected with red latex, 2....
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Effects of CIDE-B on Neuronal Apoptosis and the Characteristics of Neuron Apoptosis Induced by Rabbit
Background:The firearm injury of peripheral nerve is one of the most common injuries both in war time and peace time, and its morbidity has a tendency to increase. Although that there have been great progress in the research on peripheral ne....
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The Study of Biological and Genetic Characters of Cavernous Malformation in the Central Nervous Syste
With the development of neuroimagine and further understanding of the etiology of the cerebral cavernous malformation (CCM) , the importance of CCM is gradually being realized by clinicians. Now, CCM have become one of the major cerebravascu....
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Fabrication of Tissue Engineering Artificial Nerve from Human Embryonic Schwann Cells
Nerve injury is a difficult clinical problem to reconstructive surgery. Currently nerve autograft is still the main method to bridge neural defects in clinic. Because of the inherent shortcomings associated with the use of autografts,investi....
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Experimental Study of the Therapeutic Effect of Embryonic Neural Stem Cells Transplanted on the Atrop
Skeletal muscles undergo severe atrophy changes after denervation. Due to the slow growth velocity of the regenerating axons and the long distance they have to travel to reach the target muscle, skeletal muscles undergo irreversible atrophy....
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Neuron Retrograde Death after Semi or Whole Cervical Seven Nerve Root Transection and the Protective
OBJECTIVETo investigate retrograde death of dorsal root ganglion sensory neurons and spinal cord motorneurons after semi or whole C7 nerve root axotomy.To detect retrograde degeneration of dorsal root ganglion sensory neuron and spinal cord....
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Effect of Neurotrophin-3 Genetically Modified Olfactory Ensheathing Cells Transplantation on Spinal C
Spinal cord injury (SCI) is very frequent in our society, the number of cases increasesevery year, and this pathologic condition often causes permanent and irreversible functionaldeficits in the patients. The devastating consequences of this....
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The Effect of Callosotomy on Transhemispheric Cortical Plasticity Following Contralateral C7 Nerve Ro
Objective Based on findings in exploration of the rules of plastic changes in MI and SmI of adult rats following total brachial plexus root avulsion injuries, we investigated the central mechanism of transhemispheric reorganization primarily....
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Interleukin-10 Gene Therapy of Neuropathic Pain in the Chronic Constriction Injury Model
Proinflammatory cytokines appear to be of special importance in the creation of neuropathic pain. Investigators have addressed the potential therapeutic role of regulatory cytokines and several studies have shown that IL-10 protein administe....
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Experimental Study of the Impact of Fusion Protein of Neural Cell Adhesion Molecule L1-Ig(1-4) on the
The functional recovery of the injured spinal cord remains a difficult problem for neurologists. So far, there has no breakthrough in theory and no effective treatment in clinic. The major reason might lay in the complicated mechanisms of pr....
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Neuroprotective Effect and Its Mechanism of Ligustrazine on Secondary Spinal Cord Injury in Rats
Spinal cord injury (SCI) is commonly encounted in clinical orthopaedics and neurosurgery. It is estimated that the incidence rate of SCI is every year 20~40/ million in mostly coutries. At present, SCI continues to have devastating effects o....
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Inhibition of Calpain in Rat Spinal Cord Ischemia-reperfusion Injury: Evaluation of Postinjury Intrav
Spinal cord injury (SCI) occurs in various countries throughout the world with an annual incidence of 15 to 40 cases per million. Most of them were uncompletely injury that had a continuous spinal cord axis-cylinder. The only pharmacologic t....
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Expression of Cytokines and Chemokines Following Acute Spinal Cord Injury in Rats and Effect of Recom
BackgroundPrimary injury and secondary injury mechanisms are involved in the development and progress of pathology after acute spinal cord injury (SCI). Primary injury occurrs shortly after mechanical insult and causes neurological dysfuncti....
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The Mechanisms of Calcium Mediating IEGs Expression in Spinal Cord Secondary Injury
The secondary injury occurred after spinal cord injury is the primary cause of irreversible paraplegia at present time. The mechanism of the secondary injury is still kept unknown; therefore, we have no methods to impede the processes and to....
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Studies of Transplantation of Endothelial Progenitor Cells Transfected by VEGF Gene into Ischemic Myo
Background: Ischemic heart disease (IHD) is a major disease that seriously threatens human health.IHD is characterized by inadequate blood flow and tissue oxygen supply that is typically theconsquence of decreased patency of atherosclerotic....
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Study on the Signaling Transduction Mechanism of Smooth Muscle Cell Migration Induced by Rho GTPases
Background:Intimal hyperplasia is the principal cause of restenosis of blood vessels following vascular intervention or injury. Migration from the media to intima and subsequent proliferation of vascular smooth muscle cells(VSMC) are key eve....
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Dexamethasone Reduces the Systemic Inflammatory Response to Cardiopulmonary Bypass: Association with
Part I : Effects of Dexmerhasone on Toll-like receptor(TLR)2 and 4 in CD14+ monocyte of patients during and after Cardiac surgery with cardiopulmonary bypassObjective: To investigate the kinetics processes of TLR2 and TLR4 in CD 14+ monocyte....
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The Mechanism of Biodegradable External Stent Reducing Intimal Hyperplasia of Autologous Vein Graft
Objective: Coronary artery bypass grafting(CABG) using saphenous vein conduits remains thestandard for treatment of intractable angina due to coronary artery occlusive disease.However, its long-term clinical success is limited. Late vein gra....
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Structure and Cyclic Stress Imbalance on Pathogenesis of Abdominal Aortic Aneurysm
BACKGROUND Aneurysms occur most frequently in infra-renal aorta. In this study we try to reveal the underlying cause of this peculiar phenomenon. Generally, abdominal aortic aneurysms (AAAs) arise in the late stage of lifecycle, which result....
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Norvancomycin-bonded Dacron Prostheses in the Prevention of Vascular Graft Infection
Background Vascular graft infection(VGI)is one of the dreadful complications invascular surgery. Once it happens, its outcomes (death, limb loss, recurrentinfection) were very poor whether it is treated with conservative or surgicalmethods.....
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The Experimental Studies of vIL-10 Gene Transfer of Hematopoietic Stem Cells Induce Tolerance to Muri
Organ transplantation is a routine clinical procedure for patients with end-stage organ failure. Allograft rejection remains one of major complications after organ transplantation. Although successfully preventing acute rejection episodes ,....
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The Inhibition of Intima Hyperplasia with Antisense Endothelin Receptor a Oligodeoxynucleotide (AS-ET
Background : Transplant coronary artery disease remains a troublesome long term complication of heart transplantation .The character of GCAD is vascular narrowing resulting from intimal hyperplasia. The pathogenesis of intimal hyperplasia is....
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Perioperative Management of Renal Disfunction and Acute Renal Failure in Adult Patient Undergoing Car
Acute renal failure(ARF) remains a frequent and serious complications of cardiac surgery, the incidence of ARF following cardiac surgery has been reported to vary between 4% to 15%, half of them needed for haemodialysis support, it is associ....
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Donor Heart Preservation by Retrograde Cold Blood Microperfusion
The isolated, working rabbit heart model was used in this study to evaluate effects of Euro-Collins solution (EC) combing microperfusion (MP) for heart preservation. Thirty-two health N.Z. white rabbits weighing 1.9-2.3 Kg were divided into....
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Effect of Combined Drugs Pretreatment and Transforming Growth Factor Beta 1 Gene Transfer on Guinea P
Simplified Cervical cardiac xenotransplantation model of guinea pigs-SD rat were successfully established by modifed Heron's technique by cuff vessel anastomosis. A appropriate dosage of purified Chinese cobra venom factor administration sho....
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Transplanted Olfactory Ensheathing Cells Promote Injuried Spinal Cord Repair in the Rat
Transplanted olfactory ensheathing cells promote in juried spinal cord repair in the ratPart 1: Primary culture of olfactory ensheathing cells from neonatal ratolfactory bulbsObjective To culture and purify the olfactory ensheathing cells (O....
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Correlation of Brain Water Content with MRI Relaxation Time T_1 and Apparent Diffusion Coefficient St
ObjectiveBoth ischemic stroke and traumatic brain injury are common and main causes for brain injury, and brain edema, which succeeds after the two causes, is closely related to the patient's state of severity and his prognosis. In order to....
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An Experimental Study on Preventing Denervated Skeletal Muscle Atrophy by Myogenin Gene Transfer
Objective: (1) To clone full-length rat myogenin cDNA, to constructrecombinant cloning vector and to construct eukaryotic expression vector for furtherin vivo gene transfection. (2) To detect whether the eukaryotic expression vector of ratmy....