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Study of Low Pregnancy Ability of Infertility Rats with Endometriosis and Possible Curing Mechanism with Chinese Herb

Endometriosis may be defined as the presence of the functioning endometrial tissue outside of the endometrium Affacted by the ovarian hormones, the functioiung endometrial tissue can bleed. The characteristic symptoms associated with this disease are dysmenorrhea inenoxenia. sterility and mass in the abdomen, etc. Nomdays, the pathogenesis of endometrtosts have not been fully delineated and the current treatments can't produce a good curative effect Especially in patients with endomelriosis the sterility prevalence is 80%.that becomes a knotty problem to the medical field, in this paper, two points will be studied, one is endomelriosis infertility and its related factors, the other is the possible mechanism of treating EMT infertility with traditional Chinese medicine Document study and its implication According to the documents, three aspects were sununarized on the possible mechanism study of EMT infertility. Nervou EP abnormaV 13 -EP and DYNA1.13 levels increased significantly 2 Endocrine disorder: Including hyperprolactinemia luteal phase defect(LPD).. u-regular shedding of endometrium and low FSH .. LH levels ,etc the incidence of endometrium growth retardation increased highly. All that will cause ovulating obstruction and interfered in the ovum embedding and growing in the endometrtum. 3 .. immunity dysfunction: Elevation of EMAB level and varied cytokines levels may play a role in the pathogeneses of infertility associated with endometriosis for example ,the elevation of TN7F level in peritoneal fluids will interefere in the human sperm motility and hinder the combine of sperm and ovum. f3 -EP was one of the most important neurohumors that regulate (JnRH secreting and female reproduction function It associated with immunity system extensively. The nervous-endocrine dysfunction was found in the EMT patients ,such as the elevation of 13 -EP. There was positive correlation between the elevation of 13 -EP and nervous endocrine and immunity dysfunction, so that the dysfunction of nervous. endocrine and immunity was the basic reason of infertility associated with EMT. In traditional Chinese medicine, deficiency of the kidney with blood stasis was the basic pathogenesis of infertility associated with EMT. The therapeutic principle that Reinforcing the kidney and promoting blood circulation can improve the endocrine and immunity dysfunction, raise pregnancy rate .in this paper, the recipe of reinforcing the kidney and promoting blood circulation was clinical experiential recipe. It was made up of miscmage prevention bolus and four-ingredient decoction with additional ingredients. I .~ Experimental Study (1 StUdy of Low Pregnancy Ability of infertility Rats with Endometriosis EMT model was made by female S.D. rats, in which about 15.4% had sexual periods disorder. Before the estrus, 13 -EP and PRL levels increased and LH level decreased significantly compared with false operating group(FO), while after the estrus, P level decreases and TNF level increased Significantly compared with FO group. It was showed in the pregnancy teats that there were lower ovulatory number live foctus ~embedding rate the weight and lenth of 1 6-day-pregnancy fetal and pacental weight in the EMT group than in the FO group. When NQT was used in the EMT rats before the estrue, It was observed that rats all kept normal sexual periods in the NQTgroup. 13 -EP reduced significantly in EMT group compared with FO group while LH increased significantly compared with the EMT group

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