ABSTRACT ABSTRACT This thesis observe the clinical curative effect of the 58 patients who are in the position Chronic Renal Failure (CRF) at the same time have large quantity of albuminuria. The results show; the Renal Failure III pellet (RFIII) which is combinated by the principle fortify the spleen and boost the kidney has the notable effection obviously exceed the contrast group. The RFIII can ease the patient抯 symptoms effectly; lessen the contain of the albuminuria; reduce the level of the Cr and BUN in blood, at the same time can improve the level of the Ccr. Can ameliorate the altitude congealling positions of the CRF; correct the anaemia positions inprove the contain of ALB in the blood plasma. Keep the remains renal funation, slow down the speed of deterioration of CRF. The foundamental studies observe the ADR-Nephritis rabbits models. Use the optics microscope election microscope immunity tissue chemical and biology method observe the pathological changes of the kidney tissue. TGF- P ~, PDGF- P express situation in kidney and the changes of the renal exponent~ Scr~ BUN and Ccr, the changes of albumnuria of 24 hours (Uprot) and ALB, the changes of the SOD. MDA in the blood plasma and the changes of the MDA and GSH-PX of the kidney tissue and the changes of the UNAG and U P 2-MG. The results show, the RFIII can restrain the accumlation of the extracellular substance by decline the expression of TGF- P ~, can restrain the hyperplasia of the renal glomerulus mesentery by decline the expression of PDGF- P1. At the same time, the RFIII can improve the activety of the GSH-PX in the kidney tissue, reduce the contains of the MDA in the kidney tissue; improve the activety of the SOD in the blood plasma, reduce the contains of the MDAin the blood plasma, make clear the RFIII have the antioxidational ability of the tallow, can keep the renal glomerulus function indirectly, at the same time the RFIII can lessen the contain of the Uprot~ improve the contain of ALB in the blood plasma; correct the disorder positions of the tallow metabolization, correct the anaemia positions, reduce the level of Scr and BUN. Improve the level of Ccr. Slow down the speed of deterioration of CRF.